When one has reached a level of insobriety that they can no longer control themselves or be expected to perform any reasonable human action (e.g. exercise bladder control, regulate speech volume, and/or maintain proper etiquette). This state is inspired by the levels of insobriety shown by Wiz Khalifa (see "Taylor Gang" video by Wiz Khalifa).
He just walked into a wall and can't stop yelling. He has definitely gone Wizsane. But watch, he'll be kneeling in the bathroom in ten minutes chanting to the porcelain gods.